Medtronic 2014 Annual Report Download - page 15

Biologics Products. Products in our Biologics platform include INFUSE Bone Graft (InductOs in the European Union (EU)),
which contains a recombinant human bone morphogenetic protein, rhBMP-2, for certain spinal, trauma, and oral maxillofacial
applications, Demineralized Bone Matrix (DBM) products, including MagniFuse, Grafton/Grafton Plus, and PROGENIX, and
the MASTERGRAFT family of synthetic bone graft products - Matrix, Putty, and Granules.
The charts below set forth net sales of our Spine products as a percentage of our total net sales for each of the last three fiscal
years:
Fiscal Year 2012
(dollars in millions)
Spine
$3,267
All Other
$12,917
Fiscal Year 2013
(dollars in millions)
All Other
$13,459
Spine
$3,131
Fiscal Year 2014
(dollars in millions)
All Other
$13,964
Spine
$3,041
18%
82%
19%
81%
20%
80%
Customers and Competitors
The primary medical specialists who use our Spine products are spinal surgeons, neurosurgeons, orthopedic surgeons, and
interventional radiologists. Competitors in this business include DePuySynthes, a Johnson & Johnson Company,
Stryker Corporation (Stryker), NuVasive, Inc., Globus Medical, Inc., Zimmer Holdings, Inc. (Zimmer), Alphatec Holdings, Inc.,
K2M Group Holdings, Inc., LDR Holding Corporation, Orthofix International N.V., Biomet, Inc., and over 200 smaller
competitors and physician-owned distributorships.
Neuromodulation
Our Neuromodulation business includes implantable neurostimulation and targeted drug delivery systems for the management
of chronic pain, common movement disorders, spasticity, and urologic and gastrointestinal disorders. Neurostimulation uses an
implantable medical device, similar to a pacemaker, called a neurostimulator.
The following are the principal products offered by our Neuromodulation business:
Neurostimulation Systems for Chronic Pain. Neurostimulation therapy for chronic pain uses a neurostimulator to deliver
mild electrical impulses to the spinal cord, which act to block pain signals from the brain. We have the largest portfolio of
neurostimulation systems in the industry, including rechargeable and non-rechargeable devices and a large selection of leads
used to treat chronic back and/or limb pain. Our portfolio of products includes pain neurostimulation systems with SureScan
MRI Technology, including the RestoreSensor (rechargeable) SureScan MRI, with its proprietary AdaptiveStim technology.
Other products include the RestoreULTRA (rechargeable), RestoreADVANCED (rechargeable), and PrimeADVANCED (non-
rechargeable) neurostimulation systems.
Implantable Drug Infusion Systems. The SynchroMed II Implantable Infusion System delivers small quantities of drug
directly into the intrathecal space surrounding the spinal cord. These devices are used to treat chronic, intractable pain and
severe spasticity associated with cerebral palsy, multiple sclerosis, spinal cord and traumatic brain injuries, and stroke.
Deep Brain Stimulation (DBS) Systems. DBS uses a neurostimulator to deliver mild electrical pulses to precisely targeted
areas in the brain. DBS is currently approved in many countries around the world for the treatment of the disabling symptoms of
essential tremor, Parkinson’s disease, refractory epilepsy (outside the U.S.), severe, treatment-resistant obsessive-compulsive
disorder (approved under a HDE in the U.S.), and chronic, intractable primary dystonia (approved under a HDE in the U.S.).
Our family of Activa Neurostimulators for DBS includes Activa SC (single-channel primary cell), Activa PC (dual channel
primary cell), and Activa RC (dual channel rechargeable).
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