Nikon 2005 Annual Report Download - page 17

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DIGITAL ECLIPSE C1si
Spectral imaging
confocal laser scanning
microscope system
NEXIV VMR-K3040ZC
Fluorescence microscopy is a widely used laboratory
technique to observe living cells. But identifi cation of
neural or protein-protein interactions has been limited
because the technique requires staining with multiple
fl uorescent marker proteins whose fl uorescence spectra
can overlap. This problem often makes it diffi cult to
achieve proper separation of signals using conventional
optical fi lters.
Nikon’s new C1si series of biological microscopes
have a real spectral imaging confocal laser scanning
system that can gather information on wavelength (λ)
in addition to the usual four-dimensional data specifying
position (x, y, z) and time (t). Computational analysis
of this data allows precise separation of the different
fl uorescent spectral wavelengths. Simultaneous spec-
tral image acquisition on up to 32 channels also helps
minimize damage to cells. This product positions Nikon
at the forefront of advances in biological instruments,
maintaining its reputation for developing products that
place the main emphasis on living cell observation.
Nikon’s NEXIV series of CNC video measuring systems
combine technologies for optical measurement and
computational image processing to allow automatic
inspection of many different types of precision-made
parts and electronic components (by measuring the
shapes and dimensions of individual items). The latest
addition to the series, the NEXIV VMR-K3040ZC, is a
new type of machine that extends video measurements
into the third dimension of height. Besides the usual
two dimensions, the new system can also make high-
speed measurements of heights from all angles without
touching the inspected item. To achieve this feat, Nikon
applied its expertise in confocal optics to the challenge
of examining intricate shapes on a miniature scale
with high speed and precision. Moreover, by putting
the confocal optics system as well as the conventional
2-D measuring system on the same multi-use detector
head, Nikon developed a system that can supply either
2-D or 3-D measurements from the same perspective.
Applications for this instrument include QC inspection
of miniaturized parts with particularly complex architec-
ture, such as the latest IC packages and MEMS. Nikon
expects the NEXIV VMR-K3040ZC to establish a strong
reputation in this growing fi eld.
New series of biological
microscopes make 5-D
analysis a reality
New CNC video measuring
system opens up the third
dimension
VMR-K3040ZC measuring example (solder
bumps on printed circuit board)
Height and direction measurement results
are shown in order from low position to
high position in blue, green, yellow and red,
respectively
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