Nikon 2016 Annual Report Download - page 35

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Before image analysis After image analysis
iPS cell quality assessment utilizing
image analysis
Note: Performs phase-contrast observation of iPS cells during
the culture process, identies morphological differences
in cells by image analysis.
The green area is a cell population that has original
undifferentiated cells. The red area is a cell population in
an abnormal state that deviates from the undifferentiated cells.
Super resolution microscope
N-SIM E
Inverted routine microscope
ECLIPSE Ts2
Furthermore, I believe that the joint research currently being advanced with the Center for iPS Cell Research
and Application (CiRA) at Kyoto University will also bear fruit. The aim of this research is to build a stable cultivation
management system for iPS cells, utilizing image analysis technologies for which Nikon’s microscopic observation
technologies and pattern recognition technologies will be adopted. The most important aspect in the practical appli-
cation of iPS cells is the ability to cultivate them stably and in large quantities. At present, evaluations of cell state are
made by observing them with the human eye, but utilizing Nikon technologies replaces that technique with equip-
ment that is capable of quantifying the state of the cells and of objective evaluation. We are building a stable cultiva-
tion management system based on that quantied quality evaluation information. Were the system to reach fruition,
it would enable the objective evaluation of cell state and cultivation methods as well as contribute greatly to the
homogenization of iPS cells. We will continue to develop the Nikon system horizontally at CiRA—an iPS cell research
hub—and then work diligently to reach a future stage at which the system is used by other facilities as well.
Q Please provide us with the main points of your achievements toward the
Medium-Term Management Plan.
The most important point in the current scal year will be our start in the regenerative medicine-related business.
To steadily nurture the seeds of business that we have gained from the joint research up to now, our policy will be to
proactively advance collaborations with related companies and research organizations. As far as possible, I would
like to cultivate a number of business pillars from even just one of these seeds.
Under its slogan of “contribute to people’s health through science,” the Microscope Solutions Business Unit
regards cell imaging as its core technology. We would like to proactively face the challenges of entering businesses
in which we will be truly capable of utilizing our technologies and contributing to people’s health.
Overview of Divisions and Business Units
33
NIKON REPORT 2016
BUSINESS PERFORMANCE